A prospective 14-year longitudinal follow-up of dementia in persons with Down syndrome
McCarron et al. (2014) report on a prospective longitudinal study of a convenience sample of people with Down syndrome (DS) attending a memory clinic within an Intellectual Disability service in Dublin. Seventy-seven women with DS over the age of 35 were enrolled and assessed in a specialist memory clinic service for symptoms of dementia on an annual basis until death. Over a 14 year follow-up period it was found that almost 90% of the women had developed dementia. The mean age at which they developed dementia was 55 years. The study also assessed for co-morbidities and found that epilepsy was significantly more common in those with DS and dementia.
MCCARRON, M., NCCAILLON, P., REILLY, E. and MULRYAN, N. 2014. A prospective 14-year longitudinal follow-up of dementia in persons with Down syndrome. Journal of Intellectual Disability Research. 58(1), pp 61–70.