Screening for Alzheimer’s disease in Downs Syndrome

O’Caoimh, Clune and Molloy (2013) review instruments that are commonly used to screen for Alzheimer’s disease and explore the unique challenges of screening for the presence of Alzheimer’s disease in persons with Down syndrome. The paper concludes that single, one-dimensional screening tools and opportunistic evaluations are insufficient for detecting dementia in persons with Down syndrome. The paper argues that a better approach is to use batteries of tests, incorporating informant questionnaires, direct neuropsychological testing, assessment of activities of daily living and behaviours, measured at baseline and reassessed at intervals. 

Title: 
Screening for Alzheimer’s disease in Downs Syndrome
Date: 
2013
References: 

O’CAOIMH, R., CLUNE, Y. and MOLLEY, W.D. 2013. Screening for Alzheimer’s disease in Downs Syndrome, Journal of Alzheimer’s Disease and Parkinsonism. 3(3): S7: 1-6.