Correlates of frailty In Alzheimer’s Disease and Mild Cognitive Impairment
Ni Mhaolain et al. (2011) examine the relationship between frailty and a range of domains including age, comorbidity, course of illness, cognitive impairment, functional limitations and abnormalities of behaviour in a group of patients with AD and MCI. The study found that 51% of the patients were robust or not-frail, with 49% at an intermediate or complete stage of frailty. It suggests that escalating frailty is positively associated with increasing number of medical comorbidities and advancing age rather than being a marker of cognitive decline and severity of illness. The study suggests that optimising the management of co-morbid illness in people with dementia may play a role in minimizing the health impact of frailty in this group.
NI MHAOLAIN, A., GALLAGHER, D., CROSBY, L., RYAN, D., LACEY, L., COEN, R., BRUCE, I., WALSH, J.B., CUNNINGHAM, C., LAWLOR, B.A., et al. 2011. Correlates of frailty In Alzheimer’s Disease and Mild Cognitive Impairment. Age and Ageing, 40(5), pp. 630-633.